Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_48
Snippet: In vitro studies show that cells primed with type I IFNs are able to mount an innate response to an infecting virus, despite viral antagonism. Type I IFN signal transduction turns on transcriptional programs within cells that can decrease the inhibitory effects of the viral antagonists upon infection. Not only does the virus replicate poorly in cells primed with type I IFNs, but also primed cells can secrete pro-inflammatory cytokines more effici.....
Document: In vitro studies show that cells primed with type I IFNs are able to mount an innate response to an infecting virus, despite viral antagonism. Type I IFN signal transduction turns on transcriptional programs within cells that can decrease the inhibitory effects of the viral antagonists upon infection. Not only does the virus replicate poorly in cells primed with type I IFNs, but also primed cells can secrete pro-inflammatory cytokines more efficiently. It is known that pre-exposure of DCs to type I IFNs upregulates costimulatory molecules and major histocompatibility class I and II (MHCI and MHCII) molecules, improving their function as antigen presenting cells [114] [115] [116] .
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