Calf-Level Factors Associated with Bovine Neonatal Pancytopenia – A Multi-Country Case-Control Study

Jones, Bryony A.; Sauter-Louis, Carola; Henning, Joerg; Stoll, Alexander; Nielen, Mirjam; Van Schaik, Gerdien; Smolenaars, Anja; Schouten, Matthijs; den Uijl, Ingrid; Fourichon, Christine; Guatteo, Raphael; Madouasse, Aurélien; Nusinovici, Simon; Deprez, Piet; De Vliegher, Sarne; Laureyns, Jozef; Booth, Richard; Cardwell, Jackie M.; Pfeiffer, Dirk U.

Other dam BVD vaccinations ( Table 4, Table S5 ). After PregSure, Bovilis BVD (MSD Animal Health) was the most commonly used BVD vaccine, followed by Rispoval 3 (containing BVD, Respiratory Syncytial Virus -RS, and Parainfluenza type 3, Pfizer Animal Health) and Bovidec BVD (Novartis Animal Health). Case dams were more likely to have received Bovilis BVD, Bovidec BVD and Mucosiffa (Merial) than control dams. There was no evidence of an association between case/control status and Rispoval BVD, Rispoval RS-BVD, Rispoval 3 or Mucobovin (Merial) vaccination of dams. Some of these variables were correlated with BVD vaccination (all types of vaccine) and PregSure variables. There were 26 BVD vaccine combinations and 34 BVD vaccination sequences (Tables S7, S8 ). The most common combination was PregSure and Bovilis BVD (22%) and the most common sequence of BVD vaccines was PregSure followed by Bovilis BVD (21%). When the BVD vaccine combinations were regrouped into five categories (Table S5) , case dams were more likely to have received PregSure in combination with other BVD vaccines than PregSure only, compared with control dams. When the BVD vaccine sequence variable was regrouped into eight categories (Table S5) , case dams had increased odds of having received one or more other BVD vaccine then PregSure, or receiving one or more other BVD vaccine, then PregSure, then one or more other BVD vaccine, rather than PregSure only, compared with control dams. These variables were correlated with the other BVD vaccination variables so they were added separately to the model. Other dam vaccinations (Table 4, Table S5 ). Case dams had increased odds of having received bluetongue or IBR vaccination, and being vaccinated against more diseases, compared with control dams. There was no association between case/ control status and dams receiving rota/coronavirus or other vaccines. These variables were correlated with each other and with some of the other vaccine variables.