Author: Perra, Léa; Balloy, Viviane; Foussignière, Tobias; Moissenet, Didier; Petat, Hortense; Mungrue, Imran N.; Touqui, Lhousseine; Corvol, Harriet; Chignard, Michel; Guillot, Loic
Title: CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa Document date: 2018_11_29
ID: 10fe70kl_40
Snippet: In our study, CHAC1 mRNA induction by LPS and Pa was not related to PERK activation, as is TM, but was dependent on ATF4. In contrast, LPS from E. coli has previously been shown to activate both PERK and ATF4 in A549 cells (33) . Notably, ATF4 has been shown to be directly recruited by TLR4 independent of ER stress in human monocytes (34) . Consistent with our results, another ER stress-associated molecule, GADD34, was recently shown to be upregu.....
Document: In our study, CHAC1 mRNA induction by LPS and Pa was not related to PERK activation, as is TM, but was dependent on ATF4. In contrast, LPS from E. coli has previously been shown to activate both PERK and ATF4 in A549 cells (33) . Notably, ATF4 has been shown to be directly recruited by TLR4 independent of ER stress in human monocytes (34) . Consistent with our results, another ER stress-associated molecule, GADD34, was recently shown to be upregulated by several virulence factors from Pa, including pyocyanin and AprA, independent of PERK but dependent on ATF4 (35) . Taken together, these results were consistent with emerging evidence showing that induction of the UPR pathway by microorganisms did not reflect ER stress but was an integral part of the immune response and TLR pathways (36) .
Search related documents:
Co phrase search for related documents- ER stress and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- ER stress and PERK activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- ER stress and TLR pathway: 1
- ER stress and UPR pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- ER stress and UPR pathway induction: 1
- human monocyte and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- immune response and TLR pathway: 1, 2, 3, 4, 5, 6, 7, 8
- immune response and UPR pathway: 1
- immune response and virulence factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- Pa virulence factor and virulence factor: 1
- PERK activation and UPR pathway: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date