Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_146
Snippet: Similarly, significant inhibition of more than 50% at a concentration of 163.93 µg/mL was exhibited by the ethanol extracts of seaweeds which included E. stolonifera, E. cava, Pelvetia siliquosa, Undaria pinnatifida, and Grindelia tenella. Since the marked ACE inhibitory activity was exhibited by crude extract of E. stolonifera, it was fractionated with several solvents in order to determine the ACE inhibitory properties between the concentratio.....
Document: Similarly, significant inhibition of more than 50% at a concentration of 163.93 µg/mL was exhibited by the ethanol extracts of seaweeds which included E. stolonifera, E. cava, Pelvetia siliquosa, Undaria pinnatifida, and Grindelia tenella. Since the marked ACE inhibitory activity was exhibited by crude extract of E. stolonifera, it was fractionated with several solvents in order to determine the ACE inhibitory properties between the concentrations of 32.69 and 169.72 µg/mL. Fucosterol and six phlorotannins (phloroglucinol, dioxinodehydroeckol, eckol, phlorofucofuroeckol-A, dieckol, and triphlorethol-A) were successively isolated from the EtOAc fraction. Eckol, phlorofucofuroeckol-A, and dieckol displayed IC 50 values of 70.82 ± 0.25, 12.74 ± 0.15, and 34.25 ± 3.56 µM, respectively, showing the importance of a closed-ring dibenzo-1,4-dioxin moiety to the observed ACE-inhibition [28] .
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