Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_154
Snippet: In the viral lifecycle, neuraminidase (NA) plays a critical role as a target in the development of drugs against influenza. A high NA-inhibitory activity (72.1% inhibition at 30 µg/mL) of EtOAc layer of ethanol extract of E. cava led to bioactivity-guided fractionation and isolation of five phlorotannins (phloroglucinol, eckol, 7-phloroeckol, phlorofucofuroeckol, and dieckol). The inhibitory activity and kinetic behavior of these phlorotannins w.....
Document: In the viral lifecycle, neuraminidase (NA) plays a critical role as a target in the development of drugs against influenza. A high NA-inhibitory activity (72.1% inhibition at 30 µg/mL) of EtOAc layer of ethanol extract of E. cava led to bioactivity-guided fractionation and isolation of five phlorotannins (phloroglucinol, eckol, 7-phloroeckol, phlorofucofuroeckol, and dieckol). The inhibitory activity and kinetic behavior of these phlorotannins were examined against NA using various strains of influenza virus which includes A/Bervig_Mission/1/18 (H1N1), A/PR/8/34 (H1N1), A/Hong Kong/8/68 (H3N2), and A/Chicken/Korea/MS96/96 (H9N2). Eckol demonstrated a moderate IC 50 value of 89.5 µM against A/Bervig_Mission/1/18 (H1N1), but failed to show any significant inhibition on the other virus strains (IC 50 > 200 µM) compared with the other tested compounds (7-phloroeckol, phlorofucofuroeckol, and dieckol). The IC 50 of the compounds increased with the increase in hydroxyl groups (eckol to dieckol), indicating the significant and definite NA inhibitory activity due to the number of hydroxyl groups on the structure of phlorotannins [66] .
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