Author: Orwoll, Benjamin E.; Sapru, Anil
Title: Biomarkers in Pediatric ARDS: Future Directions Document date: 2016_6_1
ID: 0n5apnle_19
Snippet: Soluble receptor for advanced glycation end products (sRAGE) is a protein that is preferentially expressed on the basolateral membrane of alveolar type 1 cells, which are the predominant epithelial surface cells in the lung (123) . Adults' studies have shown elevations in plasma and BAL fluid sRAGE in ARDS (124) , and elevated plasma sRAGE is correlated with increased mortality, organ failure, and reduced alveolar fluid clearance (125, 126) . Ped.....
Document: Soluble receptor for advanced glycation end products (sRAGE) is a protein that is preferentially expressed on the basolateral membrane of alveolar type 1 cells, which are the predominant epithelial surface cells in the lung (123) . Adults' studies have shown elevations in plasma and BAL fluid sRAGE in ARDS (124) , and elevated plasma sRAGE is correlated with increased mortality, organ failure, and reduced alveolar fluid clearance (125, 126) . Pediatric studies have demonstrated increased plasma sRAGE in patients with bronchiolitis and with RDS (37, 38) , and plasma sRAGE from pediatric postoperative cardiac surgery patients were associated with development of ALI as well as with worse oxygenation and longer periods of mechanical ventilation (39) . It has been noted that BAL fluid sRAGE levels may vary inversely with age, which should be accounted for in future studies, though no such variations have been reported with plasma sRAGE (127) .
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