Author: Orwoll, Benjamin E.; Sapru, Anil
Title: Biomarkers in Pediatric ARDS: Future Directions Document date: 2016_6_1
ID: 0n5apnle_7_1
Snippet: h these findings have yet to be reproduced in other pediatric cohorts. Tumor necrosis factor alpha (TNF-α) and its soluble receptors (sTNFR-1 and sTNFR-2) have diverse effects on the immune system and have been associated with both ARDS development and outcomes in adults (74, 78) . The role of TNF-related activity in pARDS is less clear. A study of healthy neonates subjected to mechanical ventilation found increases in TNF-α and IL-6 in trachea.....
Document: h these findings have yet to be reproduced in other pediatric cohorts. Tumor necrosis factor alpha (TNF-α) and its soluble receptors (sTNFR-1 and sTNFR-2) have diverse effects on the immune system and have been associated with both ARDS development and outcomes in adults (74, 78) . The role of TNF-related activity in pARDS is less clear. A study of healthy neonates subjected to mechanical ventilation found increases in TNF-α and IL-6 in tracheal aspirate fluid (60) and plasma TNF-α levels were correlated with other cytokine levels, including IL-1α and IL-10 among children in a randomized controlled trial of corticosteroids for ARDS (20) , suggesting a possible role in pARDS.
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