Author: Jiang, Yuting; Zhao, Guangyu; Song, Nianping; Li, Pei; Chen, Yuehong; Guo, Yan; Li, Junfeng; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Sun, Shihui; Zhou, Yusen
Title: Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV Document date: 2018_4_24
ID: 0kihygau_22
Snippet: Statistical analyses were performed using the GraphPad Prism, version 5.01. Student's t test was used to compare the treatment and sham groups to assess semiquantitative histopathological damage, viral RNA copies, and titers in lungs, inflammatory cytokine/chemokine levels, and semi-quantitative splenocyte apoptosis and regeneration. To compare C5a and C5aR expression levels in sera and lung tissues, respectively, one-way analysis of variance wit.....
Document: Statistical analyses were performed using the GraphPad Prism, version 5.01. Student's t test was used to compare the treatment and sham groups to assess semiquantitative histopathological damage, viral RNA copies, and titers in lungs, inflammatory cytokine/chemokine levels, and semi-quantitative splenocyte apoptosis and regeneration. To compare C5a and C5aR expression levels in sera and lung tissues, respectively, one-way analysis of variance with Dunnett's post-test was used. The significance between survival curves was analyzed by Kaplan-Meier survival analysis with a log-rank test. P values lower than 0.05 were considered significant.
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