Author: Geng, Lingling; Liu, Zunpeng; Zhang, Weiqi; Li, Wei; Wu, Zeming; Wang, Wei; Ren, Ruotong; Su, Yao; Wang, Peichang; Sun, Liang; Ju, Zhenyu; Chan, Piu; Song, Moshi; Qu, Jing; Liu, Guang-Hui
Title: Chemical screen identifies a geroprotective role of quercetin in premature aging Document date: 2018_8_1
ID: 1mrj6nb3_36
Snippet: enriched in cell cycle, nuclear division and chromosome segregation pathways, consistent with the cellular phenotypes observed. Previous studies on Que have mainly focused on its anti-carcinogenic (Ansgar, 2013; Darband Saber et al., 2018) , anti-inflammatory (Griffiths et al., 2016; Li et al., 2016a; Liu et al., 2017; Salvatore, 2010) , anti-viral (Chiow et al., 2016; Li et al., 2016a) , as well as anti-oxidant effects (Sohn et al., 2018) . Howe.....
Document: enriched in cell cycle, nuclear division and chromosome segregation pathways, consistent with the cellular phenotypes observed. Previous studies on Que have mainly focused on its anti-carcinogenic (Ansgar, 2013; Darband Saber et al., 2018) , anti-inflammatory (Griffiths et al., 2016; Li et al., 2016a; Liu et al., 2017; Salvatore, 2010) , anti-viral (Chiow et al., 2016; Li et al., 2016a) , as well as anti-oxidant effects (Sohn et al., 2018) . However, the mechanisms of Que against human stem cell aging remain to be elucidated. For the first time, we showed that Que alleviated hMSC aging at least partially via the reduction of ROS, and restoration of
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