Author: Geng, Lingling; Liu, Zunpeng; Zhang, Weiqi; Li, Wei; Wu, Zeming; Wang, Wei; Ren, Ruotong; Su, Yao; Wang, Peichang; Sun, Liang; Ju, Zhenyu; Chan, Piu; Song, Moshi; Qu, Jing; Liu, Guang-Hui
Title: Chemical screen identifies a geroprotective role of quercetin in premature aging Document date: 2018_8_1
ID: 1mrj6nb3_4
Snippet: In this study, we screened a natural product library for geroprotective drugs using WS hMSCs and identified ten candidate compounds including quercetin. Mechanistically, quercetin alleviated hMSC senescence by promoting the self-renewal and differentiation abilities as well as restoring the heterochromatin architecture of WS hMSCs. RNA-sequencing analysis revealed that quercetin rejuvenated WS hMSCs via the regulation of multiple cellular process.....
Document: In this study, we screened a natural product library for geroprotective drugs using WS hMSCs and identified ten candidate compounds including quercetin. Mechanistically, quercetin alleviated hMSC senescence by promoting the self-renewal and differentiation abilities as well as restoring the heterochromatin architecture of WS hMSCs. RNA-sequencing analysis revealed that quercetin rejuvenated WS hMSCs via the regulation of multiple cellular processes related to cell cycle, chromosome condensation and anti-oxidation, which were of mechanistic commonalities for VC-mediated geroprotective effects in WS hMSCs. In addition, quercetin rejuvenated HGPS as well as physiological-aging hMSCs. Taken together, these data indicate quercetin as a geroprotective agent against premature and physiological human aging.
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