Selected article for: "peptidase degradation stability and variable region"
Author: Carabineiro, Sónia Alexandra Correia
Title: Applications of Gold Nanoparticles in Nanomedicine: Recent Advances in Vaccines †
  • Document date: 2017_5_22
    • ID: 0nz0qioh_37
    Snippet: It was shown that conjugation to negatively charged gold glyconanoparticles could stabilize either the alpha-helix or beta-strand conformation of the third variable region (V3 peptide) of the HIV-1 gp120 [101] . The peptide on the nanoparticles shows more stability toward peptidase degradation compared to the free peptide. V3 beta-glyconanoparticles produce antibodies in rabbits that recognize a recombinant gp120, and the serum showed consistent .....
    Document: It was shown that conjugation to negatively charged gold glyconanoparticles could stabilize either the alpha-helix or beta-strand conformation of the third variable region (V3 peptide) of the HIV-1 gp120 [101] . The peptide on the nanoparticles shows more stability toward peptidase degradation compared to the free peptide. V3 beta-glyconanoparticles produce antibodies in rabbits that recognize a recombinant gp120, and the serum showed consistent neutralizing activity. These results potentially allow for the design of new fully synthetic HIV vaccine candidates [101] .

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