Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons

Klaile, Esther; Klassert, Tilman E; Scheffrahn, Inka; Müller, Mario M; Heinrich, Annina; Heyl, Kerstin A; Dienemann, Hendrik; Grünewald, Christiane; Bals, Robert; Singer, Bernhard B; Slevogt, Hortense

Paraffin sections of human lung tissue from surgical specimens of lung cancer patients (N=19) were stained for CEACAM1, CEACAM5, and CEACAM6. Figure 1 shows representative pictures for these stainings. Non-cancer tissues were analyzed for the co-expression of CEACAM1, CEACAM5 and CEACAM6. Numbers of specimens with the respective pattern denominated in column 1 are given. *Assessment of total staining includes alveolar epithelium, bronchial epithelium, adventitia submucosa, pleura and blood vessel endothelium, and excludes present blood cells due to intrinsic peroxidase activity. §One or more stainings for CEACAM1, CEACAM5 or CEACAM6 are missing for this tissue in a specimen preventing an evaluation. Paraffin sections of human lung tissue from surgical specimens of lung cancer patients (N=19) were stained for CEACAM1, CEACAM5, CEACAM6, CEACAM8 and an unspecific control IgG. Figure 1 shows representative pictures for these stainings. Relative total stainings (including alveolar epithelium, bronchial epithelium, adventitia submucosa, pleura and blood vessel endothelium) were assessed in the range of 0 (no staining) to 3 (strong staining). Numbers given are mean intensity and standart deviation. No significant differences were found in comparison to the respective control groups according to two-tailed Student's t-test.