Author: Klaile, Esther; Klassert, Tilman E; Scheffrahn, Inka; Müller, Mario M; Heinrich, Annina; Heyl, Kerstin A; Dienemann, Hendrik; Grünewald, Christiane; Bals, Robert; Singer, Bernhard B; Slevogt, Hortense
Title: Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons Document date: 2013_8_14
ID: 1fmsipqu_57
Snippet: CEACAM6 expression was not altered by any agent used in this investigation ( Figure 3D ). This was probably due to its initially high expression level in the NHBE cells. Fahlgren et al. showed that the LS174T cell line that expressed high levels of CEACAM5 and CEACAM6 before IFNγ treatment did not show any enhanced expression after IFNγ exposure while IFNγ up-regulated both mRNAs in two cell lines, HT-29 and T84, that initially expressed low l.....
Document: CEACAM6 expression was not altered by any agent used in this investigation ( Figure 3D ). This was probably due to its initially high expression level in the NHBE cells. Fahlgren et al. showed that the LS174T cell line that expressed high levels of CEACAM5 and CEACAM6 before IFNγ treatment did not show any enhanced expression after IFNγ exposure while IFNγ up-regulated both mRNAs in two cell lines, HT-29 and T84, that initially expressed low levels of CEACAM5 and CEACAM6 [66] . However, the very high and constant CEACAM6 expression in NHBE cells as well as in the lung specimens is in accordance with its proposed role as a surfactant [58, 78] .
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