Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_116
Snippet: A recent study evaluated E. cava extract on its antioxidant potential in airborne particulate matter (PM) (diameter < 10 µm (PM 10 )) exposed cultured keratinocytes. The cultured HaCaT keratinocytes exposed to PM 10 in the presence and absence of E. cava extract were evaluated for their cell viability and cellular lipid peroxidation. Human epidermal keratinocytes exposed to PM 10 (100 µg/mL) were used to examine the action of eckol and dieckol .....
Document: A recent study evaluated E. cava extract on its antioxidant potential in airborne particulate matter (PM) (diameter < 10 µm (PM 10 )) exposed cultured keratinocytes. The cultured HaCaT keratinocytes exposed to PM 10 in the presence and absence of E. cava extract were evaluated for their cell viability and cellular lipid peroxidation. Human epidermal keratinocytes exposed to PM 10 (100 µg/mL) were used to examine the action of eckol and dieckol on cellular lipid peroxidation and cytokine expression.. There was a decrease in cell viability and an increase in lipid peroxidation when HaCaT cells were exposed to PM 10 , which was attenuated by E. cava extract (25, 50, 75 or 100 µg/mL) and its ethyl acetate (EtOAc) fraction (100 µg/mL). As compared to eckol (3 µg/mL), dieckol (10 µg/mL) attenuated cellular lipid peroxidation more effectively in both HaCaT cells and human epidermal keratinocytes. The inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) expression was also attenuated by dieckol and eckol in human epidermal keratinocytes stimulated with PM 10 [12] .
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