Selected article for: "cell cycle and WS hMSCs"
Author: Geng, Lingling; Liu, Zunpeng; Zhang, Weiqi; Li, Wei; Wu, Zeming; Wang, Wei; Ren, Ruotong; Su, Yao; Wang, Peichang; Sun, Liang; Ju, Zhenyu; Chan, Piu; Song, Moshi; Qu, Jing; Liu, Guang-Hui
Title: Chemical screen identifies a geroprotective role of quercetin in premature aging
  • Document date: 2018_8_1
    • ID: 1mrj6nb3_21
    Snippet: were upregulated (Fig. 7C ). Given that all these genes were NRF2 responsive genes, we tested whether the anti-oxidative function of Que was NRF2-dependent by evaluating the expression levels of NRF2 target genes. The results showed that NRF2 target genes were upregulated (P < 0.0001) upon Que treatment (Fig. 7D ). The increased expression levels of GSTP1, GSR, SOD1 and SOD2 in WS hMSCs upon Que treatment was reconfirmed by RT-qPCR analysis (Fig......
    Document: were upregulated (Fig. 7C ). Given that all these genes were NRF2 responsive genes, we tested whether the anti-oxidative function of Que was NRF2-dependent by evaluating the expression levels of NRF2 target genes. The results showed that NRF2 target genes were upregulated (P < 0.0001) upon Que treatment (Fig. 7D ). The increased expression levels of GSTP1, GSR, SOD1 and SOD2 in WS hMSCs upon Que treatment was reconfirmed by RT-qPCR analysis (Fig. 7E ). Taken together, these data suggest that Que rejuvenated WS hMSCs via the regulation of multiple cellular processes including promoting cell cycle, condensing chromosome, and enhancing anti-oxidation.

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