Author: Geng, Lingling; Liu, Zunpeng; Zhang, Weiqi; Li, Wei; Wu, Zeming; Wang, Wei; Ren, Ruotong; Su, Yao; Wang, Peichang; Sun, Liang; Ju, Zhenyu; Chan, Piu; Song, Moshi; Qu, Jing; Liu, Guang-Hui
Title: Chemical screen identifies a geroprotective role of quercetin in premature aging Document date: 2018_8_1
ID: 1mrj6nb3_39
Snippet: In this study, we showed that Que and VC exerted cooperative effects attenuating accelerated senescence in HGPS hMSCs. Besides VC, other geroprotective chemicals could also strengthen the biological activity of Que. For example, resveratrol and Que exhibit synergistic effects in the restoration of genes in pathways of glucose/lipid metabolism, liver function, cardiovascular system, and inflammation/immunity in mice fed with high-fat diet (Zhou et.....
Document: In this study, we showed that Que and VC exerted cooperative effects attenuating accelerated senescence in HGPS hMSCs. Besides VC, other geroprotective chemicals could also strengthen the biological activity of Que. For example, resveratrol and Que exhibit synergistic effects in the restoration of genes in pathways of glucose/lipid metabolism, liver function, cardiovascular system, and inflammation/immunity in mice fed with high-fat diet (Zhou et al., 2012) . Moving forward, how to maximize the geroprotective effects of Que by combining with other components awaits further investigation.
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