Selected article for: "ifn induction and type ifn induction"
Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses
  • Document date: 2010_11_18
    • ID: 0yqv2osb_31
    Snippet: The paramyxoviruses' ability to inhibit IFN has been reviewed elsewhere [71] . In brief, Sendai virus (SeV), MeV and Mumps virus (MuV) viruses V protein can block the activation of MDA5 [72] [73] [74] [75] . Several V proteins of paramyxoviruses can inhibit IRF-3 activation [76] , for example RSV NS1 and NS2 also block IRF3 activation [77] . RSV NS2 can block type I IFN induction by binding RIG-I and inhibiting downstream signaling [78] ......
    Document: The paramyxoviruses' ability to inhibit IFN has been reviewed elsewhere [71] . In brief, Sendai virus (SeV), MeV and Mumps virus (MuV) viruses V protein can block the activation of MDA5 [72] [73] [74] [75] . Several V proteins of paramyxoviruses can inhibit IRF-3 activation [76] , for example RSV NS1 and NS2 also block IRF3 activation [77] . RSV NS2 can block type I IFN induction by binding RIG-I and inhibiting downstream signaling [78] .

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