Title: Casting a Wide Net to Fight Coronaviruses Document date: 2005_9_6
ID: 1idu68su_4
Snippet: Initial computer analysis showed that the Mpro primary protein sequences (the linear amino acid sequences) have only 38% sequence identity between coronavirus species in some cases. But because three-dimensional structures tend to be more conserved than amino-acid sequences, the authors chose representative viruses from each group of coronavirus to study and compare the structure of their Mpro. This protease normally binds to its target protein (.....
Document: Initial computer analysis showed that the Mpro primary protein sequences (the linear amino acid sequences) have only 38% sequence identity between coronavirus species in some cases. But because three-dimensional structures tend to be more conserved than amino-acid sequences, the authors chose representative viruses from each group of coronavirus to study and compare the structure of their Mpro. This protease normally binds to its target protein (called the substrate) via a specific region, called the substrate-binding site. Structural analysis determined that this site is well conserved among coronaviruses, and biochemical tests confirmed that it would make a promising target for antiviral agents.
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