Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_187
Snippet: Hair loss, also known as alopecia or baldness, describes the loss of hair from the head or body, with severity varying from a small section to the whole body. One study evaluated the effect of E. cava on the promotion of hair growth. Treatment with E. cava enzymatic extract and compounds isolated from it resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPCs). The DPCs were treated with compounds isolated from E. cava e.....
Document: Hair loss, also known as alopecia or baldness, describes the loss of hair from the head or body, with severity varying from a small section to the whole body. One study evaluated the effect of E. cava on the promotion of hair growth. Treatment with E. cava enzymatic extract and compounds isolated from it resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPCs). The DPCs were treated with compounds isolated from E. cava enzymatic extract including eckol, dieckol, phloroglucinol, or triphlorethol-A at a concentration of 0.005, 0.01, 0.05, 0.1, 0.5, 1, and 10 µg/mL for 4 days, which resulted in proliferation of DPCs by 100.8%, 106.1%, 120.3%, 108.5%, 107.8%, 105.4%, and 104.1%, respectively. Since the mitotic effect on NIH3T3 fibroblasts via the K ATP channel opening leads to the promotion of hair growth, the E. cava enzymatic extract, eckol, dieckol, phloroglucinol, and triphlorethol-A were tested for their ability on hair growth. Eckol increased the proliferation of NIH3T3 fibroblasts to some extent as compared with the control group. Eckol and dieckol also inhibited 5α-reductase activity in a dose-dependent manner which is important for preventing hair loss [149] .
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