Author: Hijano, Diego R.; Brazelton de Cardenas, Jessica; Maron, Gabriela; Garner, Cherilyn D.; Ferrolino, Jose A.; Dallas, Ronald H.; Gu, Zhengming; Hayden, Randall T.
Title: Clinical correlation of influenza and respiratory syncytial virus load measured by digital PCR Document date: 2019_9_3
ID: 1sli4e5v_37
Snippet: The association between viral load and therapeutic response seen in our study has some precedents in the literature [57, 58] . Reduction of influenza and RSV viral loads by using different treatments has been reported in several animal models [59, 60] . However, few studies report the reduction of viral loads after treatment that are associated with clinical improvement in humans, particularly children at high risk of severe infection. Clinical t.....
Document: The association between viral load and therapeutic response seen in our study has some precedents in the literature [57, 58] . Reduction of influenza and RSV viral loads by using different treatments has been reported in several animal models [59, 60] . However, few studies report the reduction of viral loads after treatment that are associated with clinical improvement in humans, particularly children at high risk of severe infection. Clinical trials of adults experimentally infected RSV show reduction in viral loads after treatment [61, 62] . Khanna et al. reported a decrease of >2 log 10 copies/mL in RSV load in 11 (58%) of 19 adult patients with hematologic malignancies within 7 days of initiating treatment [63] . Several case reports and case series have described the role of oseltamivir in decreasing viral load in respiratory secretions [40, 64, 65] . The significant reduction in viral load for both influenza virus and RSV seen in our study agrees with these studies.
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