Selected article for: "cell surface and surface molecule"
Author: McLeod, Robbie L.; Angagaw, Minilik H.; Baral, Toya Nath; Liu, Liming; Moniz, Raymond Joseph; Laskey, Jason; Hsieh, SuChun; Lee, Mike; Han, Jin-Hwan; Issafras, Hassan; Javaid, Sarah; Loboda, Andrey; Sadekova, Svetlana; O'Connor, Joann A.; Tse, Archie; Punnonen, Juha
Title: Characterization of murine CEACAM1 in vivo reveals low expression on CD8(+) T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1
  • Document date: 2018_10_2
    • ID: 01id7jq6_18
    Snippet: CEACAM1 is a pleiotropic cell surface molecule expressed on diverse cell types. Its expression levels are rapidly modulated upon activation, adding to the complexity of defining an unambiguous role of CEACAM1 in health and disease. In the current study, we (1) evaluated the potential of CC1 to block its ligand interactions, (2) studied CEACAM1 expression on TILs from syngeneic tumor models (3) defined the PK characteristics of CC1 after IP admini.....
    Document: CEACAM1 is a pleiotropic cell surface molecule expressed on diverse cell types. Its expression levels are rapidly modulated upon activation, adding to the complexity of defining an unambiguous role of CEACAM1 in health and disease. In the current study, we (1) evaluated the potential of CC1 to block its ligand interactions, (2) studied CEACAM1 expression on TILs from syngeneic tumor models (3) defined the PK characteristics of CC1 after IP administration and (4) profiled the anti-tumor effects of CC1 in syngeneic mouse models.

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