Characterizing Eckol as a Therapeutic Aid: A Systematic Review

Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue

In a similar study, eckol acted as an α 2 -P (IC 50 1.6 µg/mL), an α 2 -M (IC 50 1.8 µg/mL), an α 1 anti-trypsin (IC 50 0.8 µg/mL), and thrombin (IC 50 13 µg/mL) inhibitor. However, eckol exhibited very weak inhibition on anti-thrombin III-heparin complex and exhibited no inhibition on plasmin. The inhibitory activity of eckol was reduced in whole human plasma, but at a concentration above 200 µg/mL, it enhanced urokinase-induced fibrinolysis. The importance of dibenzo-1,4 dioxane skeleton for inhibition of plasmin inhibitors was shown by several derivatives of eckol [16] . As previously stated [120] , only the dibenzo-1,4-dioxane skeleton (dibenzo-p-dioxin-1,3,6,8-tetraol) is important for the potent anti-inhibitor activity as compared to the other hydroxyl groups present in eckol. Hence, the results suggest that a simple dibenzo-1,4-dioxane skeleton with other functional groups could be clinically useful in stimulating fibrinolysis [16] .