Author: de Miranda, Joachim R.; Hedman, Harald; Onorati, Piero; Stephan, Jörg; Karlberg, Olof; Bylund, Helena; Terenius, Olle
Title: Characterization of a Novel RNA Virus Discovered in the Autumnal Moth Epirrita autumnata in Sweden Document date: 2017_8_8
ID: 1baso3q2_25
Snippet: as sub-optimal as can be and inferior to either of the possible ORF-2 start codons (UAA 8266 AUGCGC; AAU 8473 AUGACU), neither of which are particular optimal themselves. Therefore, unless ORF-3 is translated through a dedicated IRES hidden in the CP gene (e.g., [27] ), it may well be produced as a read-through product of ORF-2, through a leaky UAG stop codon. Such a strategy has plenty of precedence elsewhere in the virus world, particularly for.....
Document: as sub-optimal as can be and inferior to either of the possible ORF-2 start codons (UAA 8266 AUGCGC; AAU 8473 AUGACU), neither of which are particular optimal themselves. Therefore, unless ORF-3 is translated through a dedicated IRES hidden in the CP gene (e.g., [27] ), it may well be produced as a read-through product of ORF-2, through a leaky UAG stop codon. Such a strategy has plenty of precedence elsewhere in the virus world, particularly for coat proteins that thus acquire extensions with potentially useful functions for cell entry, infectivity, and host-range [26] .
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