Author: Peri, Anna Maria; Verna, Marta; Biffi, Stefano; Alagna, Laura; Longhi, Benedetta; Migliorino, Guglielmo Marco; Foresti, Sergio; Bandera, Alessandra; Rovelli, Attilio; Rizzari, Carmelo; Gori, Andrea; Colombini, Antonella
Title: Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series Document date: 2019_9_5
ID: 1egushdn_2
Snippet: Controversies exist over the benefit of using a combination antifungal treatment (CAT) in this patient population. In particular, the attempt of improving the efficacy of the treatment is often balanced by concerns of a decreased safety due to cumulative toxicities. Evidence about the role of CAT for the treatment of IMI is scarce in the adult population and even more limited in the pediatric setting. In particular, well-designed studies on the u.....
Document: Controversies exist over the benefit of using a combination antifungal treatment (CAT) in this patient population. In particular, the attempt of improving the efficacy of the treatment is often balanced by concerns of a decreased safety due to cumulative toxicities. Evidence about the role of CAT for the treatment of IMI is scarce in the adult population and even more limited in the pediatric setting. In particular, well-designed studies on the use of CAT in immunocompromised children are lacking, and the current knowledge on this topic mainly relies on retrospective and prospective cohorts [1] [2] [3] [4] [5] [6] . In this scenario, any experience of treating IMI with CAT in children may help clinicians to gain knowledge in this field and hopefully serve as a starting point for further larger studies. Hence, we report our real-life case series on the use of CAT in the pediatric setting.
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