Author: Geng, Lingling; Liu, Zunpeng; Zhang, Weiqi; Li, Wei; Wu, Zeming; Wang, Wei; Ren, Ruotong; Su, Yao; Wang, Peichang; Sun, Liang; Ju, Zhenyu; Chan, Piu; Song, Moshi; Qu, Jing; Liu, Guang-Hui
Title: Chemical screen identifies a geroprotective role of quercetin in premature aging Document date: 2018_8_1
ID: 1mrj6nb3_3
Snippet: WS and HGPS are both relevant disease models for understanding the mechanisms of aging and for finding effective treatments for aging-associated disorders. We previously reported that Vitamin C (VC) rejuvenates WS hMSCs by inducing a global change in the transcriptome of aging-related genes (Li et al., 2016b) . In addition, Vitamin D is reported to improve HGPS cellular phenotypes by reducing progerin production and stabilizing key factors for ma.....
Document: WS and HGPS are both relevant disease models for understanding the mechanisms of aging and for finding effective treatments for aging-associated disorders. We previously reported that Vitamin C (VC) rejuvenates WS hMSCs by inducing a global change in the transcriptome of aging-related genes (Li et al., 2016b) . In addition, Vitamin D is reported to improve HGPS cellular phenotypes by reducing progerin production and stabilizing key factors for maintaining genome integrity (Kreienkamp et al., 2016) . We recently established a human stem-cell-based platform with isogenic WS and HGPS hMSCs with the identical genetic background for the comparative mechanistic studies of aging as well as the identification of new drug discovery strategies for progeria syndromes and physiological aging (Kubben et al., 2016; Li et al., 2016b; Liu et al., 2011a; Liu et al., 2011b; Wu et al., 2018; Zhang et al., 2015) .
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