Author: Geng, Lingling; Liu, Zunpeng; Zhang, Weiqi; Li, Wei; Wu, Zeming; Wang, Wei; Ren, Ruotong; Su, Yao; Wang, Peichang; Sun, Liang; Ju, Zhenyu; Chan, Piu; Song, Moshi; Qu, Jing; Liu, Guang-Hui
Title: Chemical screen identifies a geroprotective role of quercetin in premature aging Document date: 2018_8_1
ID: 1mrj6nb3_32
Snippet: The effects of high-dose Que have been previously evaluated in human cells and mice. The combination of dasatinib and high-dose of Que (50 mg/kg) effectively eliminates senescent cells via induced apoptosis and thus alleviated senescence-related phenotypes in mice (Zhu et al., 2015) . In Alleviating premature aging by quercetin RESEARCH ARTICLE non-alcoholic fatty liver disease (NAFLD) mice, the combination of dasatinib and Que (20 mg/kg) elimina.....
Document: The effects of high-dose Que have been previously evaluated in human cells and mice. The combination of dasatinib and high-dose of Que (50 mg/kg) effectively eliminates senescent cells via induced apoptosis and thus alleviated senescence-related phenotypes in mice (Zhu et al., 2015) . In Alleviating premature aging by quercetin RESEARCH ARTICLE non-alcoholic fatty liver disease (NAFLD) mice, the combination of dasatinib and Que (20 mg/kg) eliminates senescent cells for the reduction of overall hepatic steatosis (Ogrodnik et al., 2017) . In senescent human preadipocytes and umbilical vein endothelial cells (HUVECs), high-dose Que (optimal concentrations at 10 and 20 μmol/L, respectively) induces apoptotic cell death. By contrast, we used Que at 100 nmol/L in WS, HGPS, physiological-aging hMSCs, which effectively alleviated cellular senescence without inducing cell death, indicative of a much safer therapeutic dose potentially applicable to stimulating hMSC activity.
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