Author: Brisse, Morgan; Ly, Hinh
Title: Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5 Document date: 2019_7_17
ID: 1enteev7_58
Snippet: Despite their structural and mechanistic differences, it is important to emphasize that existing phylogenetic analysis indicates that RIG-I and MDA5 come from a common origin that is also shared among several other protein families (Figure 7) . The linkage of the helicase and DExD/H box protein appear to be ancient, as orthologs of these proteins are found in the Archaea kingdom (335, 336) . MDA5 orthologs are found in most vertebrates (184) , wh.....
Document: Despite their structural and mechanistic differences, it is important to emphasize that existing phylogenetic analysis indicates that RIG-I and MDA5 come from a common origin that is also shared among several other protein families (Figure 7) . The linkage of the helicase and DExD/H box protein appear to be ancient, as orthologs of these proteins are found in the Archaea kingdom (335, 336) . MDA5 orthologs are found in most vertebrates (184) , while RIG-I orthologs are only found in mammals, ducks, geese and some selected fish and reptiles (184, (337) (338) (339) (340) (341) (342) (343) (Figures 2, 7) .
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