Author: Peri, Anna Maria; Verna, Marta; Biffi, Stefano; Alagna, Laura; Longhi, Benedetta; Migliorino, Guglielmo Marco; Foresti, Sergio; Bandera, Alessandra; Rovelli, Attilio; Rizzari, Carmelo; Gori, Andrea; Colombini, Antonella
Title: Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series Document date: 2019_9_5
ID: 1egushdn_38
Snippet: Conflicting results are available in the literature about the association of L-AMB with azoles. Some in vitro studies have reported antagonism between the 2 drugs [21] while this combination has proven to be effective and associated with improved outcomes in animal models of CNS aspergillosis [22] [23] [24] . Although evidence is controversial, many real-life studies report the use of this combination in clinical practice in the pediatric setting.....
Document: Conflicting results are available in the literature about the association of L-AMB with azoles. Some in vitro studies have reported antagonism between the 2 drugs [21] while this combination has proven to be effective and associated with improved outcomes in animal models of CNS aspergillosis [22] [23] [24] . Although evidence is controversial, many real-life studies report the use of this combination in clinical practice in the pediatric setting [4, 5, 19] . In our case series, the combination of L-AMB with voriconazole was mainly used to treat CNS aspergillosis. Among these patients, mortality rate was high: Of note, CNS aspergillosis is historically associated with poor outcome [13] and studies are needed to establish the best treatment.
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