Author: Li, Xiao-Jun; Kim, Kwan-Woo; Oh, Hyuncheol; Liu, Xiang-Qian; Kim, Youn-Chul
Title: Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots of Acanthopanax henryi Document date: 2019_2_21
ID: 1vbkttzx_38
Snippet: Various pharmacological activities of lignans, including compound (savinin), have been reported. These activities include cytotoxic effects against human cancer cell lines [36] , CYP3A4 inactivation [37] , antisevere acute respiratory syndrome associated coronavirus (SARS-CoV) activity [38] , inhibition of PGE 2 production in rat peritoneal macrophages [39] , antiestrogenic [40] , insecticidal [41] , and inhibition of TNF-production in RAW264.7 m.....
Document: Various pharmacological activities of lignans, including compound (savinin), have been reported. These activities include cytotoxic effects against human cancer cell lines [36] , CYP3A4 inactivation [37] , antisevere acute respiratory syndrome associated coronavirus (SARS-CoV) activity [38] , inhibition of PGE 2 production in rat peritoneal macrophages [39] , antiestrogenic [40] , insecticidal [41] , and inhibition of TNF-production in RAW264.7 macrophage cells [42] ; however, this is the first finding on the antineuroinflammatory effects of compound (savinin) to the best of our knowledge.
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