Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox Document date: 2012_3_1
ID: 0mmtcbof_15
Snippet: Here, upon MVA i.n. inoculation of C57BL/6 mice we did indeed detect interleukin-6 (IL-6) and interferon-alpha (IFN-a) in BAL fluids within 6 hours and 24 hours p. i. ( Figure S5 ) suggesting TLR and RLR dependent immune activation. We therefore performed the MVA immunization/ECTV challenge experiments in MyD88/Trif 2/2 mice lacking TLR signaling ( Figure 2B ), and IPS 2/2 mice lacking RLR signaling ( Figure 2C ). Clearly, the absence of either T.....
Document: Here, upon MVA i.n. inoculation of C57BL/6 mice we did indeed detect interleukin-6 (IL-6) and interferon-alpha (IFN-a) in BAL fluids within 6 hours and 24 hours p. i. ( Figure S5 ) suggesting TLR and RLR dependent immune activation. We therefore performed the MVA immunization/ECTV challenge experiments in MyD88/Trif 2/2 mice lacking TLR signaling ( Figure 2B ), and IPS 2/2 mice lacking RLR signaling ( Figure 2C ). Clearly, the absence of either TLR or RLR signaling had no influence on the protective capacity of immunization with MVA (P = 1), confirming that several innate signaling cascades and innate immune cells can respond to MVA immunization. These likely compensate for each other in mediating sufficient immune activation to provide rapid protection.
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