Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox Document date: 2012_3_1
ID: 0mmtcbof_7
Snippet: Local immune responses to MVA Intranasal (i.n.) application of MVA vaccine can rapidly induce robust protection against lethal respiratory orthopoxvirus infections [41, 43] . However, the mechanisms of protective immunity still need to be elucidated. In particular, only limited information about local immune responses in the respiratory tract is available. Recent data suggest that in the vaccinated host MVA is recognized via multiple sensor pathw.....
Document: Local immune responses to MVA Intranasal (i.n.) application of MVA vaccine can rapidly induce robust protection against lethal respiratory orthopoxvirus infections [41, 43] . However, the mechanisms of protective immunity still need to be elucidated. In particular, only limited information about local immune responses in the respiratory tract is available. Recent data suggest that in the vaccinated host MVA is recognized via multiple sensor pathways, which results in the activation of innate immunity, including the synthesis of type I interferons (IFN) and chemokines. These innate responses will trigger attraction of immune cells to the site of immunization, which might be responsible for the rapid development of protective adaptive immunity [44] [45] [46] [47] .
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