Selected article for: "MERS CoV genome and RNA dependent RNA polymerase"
Author: Hao, Wei; Wojdyla, Justyna Aleksandra; Zhao, Rong; Han, Ruiyun; Das, Rajat; Zlatev, Ivan; Manoharan, Muthiah; Wang, Meitian; Cui, Sheng
Title: Crystal structure of Middle East respiratory syndrome coronavirus helicase
  • Document date: 2017_6_26
    • ID: 0vxhgjss_5
    Snippet: MERS-CoV has a positive single-stranded RNA (+RNA) genome of~30kb, one of the largest among +RNA viruses [4] . To support the efficient replication of its exceptionally large genome, MERS-CoV encodes two replicase polyproteins pp1a and pp1ab, which are proteolytically processed into 16 nonstructural proteins (nsps) [12, 13] . The nsps assemble into the membrane-associated replication-transcription complexes (RTCs), which drive viral genome replic.....
    Document: MERS-CoV has a positive single-stranded RNA (+RNA) genome of~30kb, one of the largest among +RNA viruses [4] . To support the efficient replication of its exceptionally large genome, MERS-CoV encodes two replicase polyproteins pp1a and pp1ab, which are proteolytically processed into 16 nonstructural proteins (nsps) [12, 13] . The nsps assemble into the membrane-associated replication-transcription complexes (RTCs), which drive viral genome replication and translation. An RNA-dependent RNA polymerase (nsp12) and a helicase (nsp13) are central components of RTC [14, 15] .

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