Selected article for: "II receptor and type II receptor"
Author: Russell, Beth; Moss, Charlotte; Rigg, Anne; Van Hemelrijck, Mieke
Title: COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting?
  • Document date: 2020_3_30
    • ID: 0uengr9t_5
    Snippet: One study within the review linked SARS-CoV to the downregulation of ACE2 [1] . This downregulation of ACE2 has previously been implicated in the loss of pulmonary function in SARS-CoV [1] . However, further data also suggested that ACE2 expression is increased through the use of ibuprofen, in diabetic patients and in those treated with angiotensin II type-I receptor blockers [2] . Consequently, it was suggested that increased expression of ACE2 .....
    Document: One study within the review linked SARS-CoV to the downregulation of ACE2 [1] . This downregulation of ACE2 has previously been implicated in the loss of pulmonary function in SARS-CoV [1] . However, further data also suggested that ACE2 expression is increased through the use of ibuprofen, in diabetic patients and in those treated with angiotensin II type-I receptor blockers [2] . Consequently, it was suggested that increased expression of ACE2 in these co-morbid patients could facilitate infection with COVID-19.

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