Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox Document date: 2012_3_1
ID: 0mmtcbof_31
Snippet: Previous work in IFNAR 2/2 mice had indicated a partial influence of type I IFN in rapid protection mediated by MVA vaccination [41] . Here we show that the protective capacity of MVA immunization was fully maintained in MyD88/Trif 2/2 and IPS 2/2 mice that are deficient in TLR and RLR signaling pathways controlling the expression of type I IFN. Nevertheless, it cannot be excluded that other innate recognition pathways are involved in mediating a.....
Document: Previous work in IFNAR 2/2 mice had indicated a partial influence of type I IFN in rapid protection mediated by MVA vaccination [41] . Here we show that the protective capacity of MVA immunization was fully maintained in MyD88/Trif 2/2 and IPS 2/2 mice that are deficient in TLR and RLR signaling pathways controlling the expression of type I IFN. Nevertheless, it cannot be excluded that other innate recognition pathways are involved in mediating a type I IFN response to MVA. Thus it seems likely that due to versatile recognition of MVA, signaling pathways can compensate for each other to provide the innate responses essential for developing protective adaptive immunity. In particular, further study of the possible contribution of type I IFN in rapidly protective MVA immunization seems promising because concomitant type I interferon receptor triggering on T cells and DC has been recently shown to allow for optimal expansion of MVA induced CD8 T cell responses [71] .
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