Selected article for: "activator signal transducer and increase expression"
Author: Brisse, Morgan; Ly, Hinh
Title: Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
  • Document date: 2019_7_17
    • ID: 1enteev7_29
    Snippet: Interferons are then secreted out of the cell, where they bind to their own receptor (IFNAR) and activate the Janus kinase/Signal Transducer and Activator of Transcription proteins (JAK/STAT) signaling pathways, which result in a positive feedback signaling loop to further increase RIG-I/MDA5 expression and activation (160) and IFN1 production (161, 162) . Expression levels of RIG-I and MDA5 have consistently been found to be upregulated downstre.....
    Document: Interferons are then secreted out of the cell, where they bind to their own receptor (IFNAR) and activate the Janus kinase/Signal Transducer and Activator of Transcription proteins (JAK/STAT) signaling pathways, which result in a positive feedback signaling loop to further increase RIG-I/MDA5 expression and activation (160) and IFN1 production (161, 162) . Expression levels of RIG-I and MDA5 have consistently been found to be upregulated downstream of type I (163, 164) and type II (165, 166) IFN signals. MDA5 upregulation has additionally been found to occur independently of cytokine expression at least during picornavirus infection (167).

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