Author: Cyktor, Joshua C.; Carruthers, Bridget; Beamer, Gillian L.; Turner, Joanne
Title: Clonal Expansions of CD8(+) T Cells with IL-10 Secreting Capacity Occur during Chronic Mycobacterium tuberculosis Infection Document date: 2013_3_5
ID: 1rhlu59c_38
Snippet: In summary, we show using an Mtb-susceptible mouse strain (CBA/J) that clonal expansions of CD8 + T cells with the capacity to produce IL-10 can arise during chronic Mtb infection. In combination with our previous finding that blocking the action of IL-10 can improve outcome of Mtb infection [5] , these data further support a negative role for IL-10 in the generation and maintenance of protective immunity against Mtb infection. Our findings are o.....
Document: In summary, we show using an Mtb-susceptible mouse strain (CBA/J) that clonal expansions of CD8 + T cells with the capacity to produce IL-10 can arise during chronic Mtb infection. In combination with our previous finding that blocking the action of IL-10 can improve outcome of Mtb infection [5] , these data further support a negative role for IL-10 in the generation and maintenance of protective immunity against Mtb infection. Our findings are of significance because vaccines that specifically stimulate CD8 + T cells are currently under development [59] [60] [61] [62] [63] . Given that IL-10-secreting CD8 + T cells with the potential to negatively impact control of Mtb infection can naturally arise, generating such cells in response to vaccination should be considered.
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