Author: Selinger, Christian; Tisoncik-Go, Jennifer; Menachery, Vineet D; Agnihothram, Sudhakar; Law, G Lynn; Chang, Jean; Kelly, Sara M; Sova, Pavel; Baric, Ralph S; Katze, Michael G
Title: Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates Document date: 2014_12_22
ID: 0y3m47lh_16
Snippet: MERS-CoV is a novel pathogenic coronavirus and the innate and inflammatory response during MERS infection is poorly understood. Using an established human airway culture model we found differences in host gene expression between MERS-CoV SA 1 and MERS-CoV Eng 1 that support the hypothesis of strain-specific differences related to functional differences in the sensitivity to innate immune responses [4] . Through our genomicsbased approach, we foun.....
Document: MERS-CoV is a novel pathogenic coronavirus and the innate and inflammatory response during MERS infection is poorly understood. Using an established human airway culture model we found differences in host gene expression between MERS-CoV SA 1 and MERS-CoV Eng 1 that support the hypothesis of strain-specific differences related to functional differences in the sensitivity to innate immune responses [4] . Through our genomicsbased approach, we found (i) topological differences in the kinetics and magnitude of the host response to MERS-CoV SA 1 and MERS-CoV Eng 1, with (i) a precursory host response in MERS-CoV Eng 1-infected cells, (ii) differential expression of innate immune and pro-inflammatory responsive genes between MERS-CoV Eng 1 and MERS-CoV SA 1 that may be associated with downstream effects of IFN, TNF and IL-1α signaling, and (iii) a predicted activation for STAT3 mediating gene expression relevant for epithelial cell remodeling in MERS-CoV Eng 1 infection.
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