Selected article for: "main protease and subgenomic rna nested set"
Author: Xu, Xiaoling; Lou, Zhiyong; Ma, Yanlin; Chen, Xuehui; Yang, Zhangsheng; Tong, Xiaohang; Zhao, Qi; Xu, Yuanyuan; Deng, Hongyu; Bartlam, Mark; Rao, Zihe
Title: Crystal Structure of the C-Terminal Cytoplasmic Domain of Non-Structural Protein 4 from Mouse Hepatitis Virus A59
  • Document date: 2009_7_10
    • ID: 1beonuh7_1
    Snippet: Coronaviruses are positive-strand RNA viruses, characterized by the largest RNA genomes and a nested set of subgenomic mRNA during transcription [1, 2, 3] . MHV strain A59 is an extensively studied group II coronavirus [4, 5] that causes enteritis, hepatitis, and central nervous system demyelination in susceptible mice [6, 7] . Translation of the MHV-A59 genome yields 16 nonstructural proteins (nsps), which are encoded by two large overlapping op.....
    Document: Coronaviruses are positive-strand RNA viruses, characterized by the largest RNA genomes and a nested set of subgenomic mRNA during transcription [1, 2, 3] . MHV strain A59 is an extensively studied group II coronavirus [4, 5] that causes enteritis, hepatitis, and central nervous system demyelination in susceptible mice [6, 7] . Translation of the MHV-A59 genome yields 16 nonstructural proteins (nsps), which are encoded by two large overlapping open reading frames (ORF) termed ORF1a and ORF1b. Expression of ORF1b requires a (21) ribosomal frameshift to yield two large polyproteins, pp1a (495 kDa) and pp1ab (803 kDa) [8, 9] . The pp1a and pp1ab polyproteins are cotranslationally and post-translationally processed by two papainlike proteases domains in nsp3, named PLP1 and PLP2, and the main protease nsp5 (Mpro) into 16 non-structural proteins [10, 11, 12, 13] . These non-structural proteins are proposed to form a membrane-anchored replication complex for RNA replication and transcription [14, 15] .

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