Author: Xu, Xiaoling; Lou, Zhiyong; Ma, Yanlin; Chen, Xuehui; Yang, Zhangsheng; Tong, Xiaohang; Zhao, Qi; Xu, Yuanyuan; Deng, Hongyu; Bartlam, Mark; Rao, Zihe
Title: Crystal Structure of the C-Terminal Cytoplasmic Domain of Non-Structural Protein 4 from Mouse Hepatitis Virus A59 Document date: 2009_7_10
ID: 1beonuh7_29
Snippet: Multiple sequence alignment of MHV-A59 nsp4 with representatives from all three groups of the genus Coronavirus reveals that the membrane topology of nsp4 from all group members is similar. In particular, the C-terminal hydrophilic region from T408 to Q496 is highly conserved among all the coronaviruses (Fig. 4B) , indicating that nsp4C may play a similar and conserved role in coronavirus replication. In summary, the crystal structure of MHV-A59 .....
Document: Multiple sequence alignment of MHV-A59 nsp4 with representatives from all three groups of the genus Coronavirus reveals that the membrane topology of nsp4 from all group members is similar. In particular, the C-terminal hydrophilic region from T408 to Q496 is highly conserved among all the coronaviruses (Fig. 4B) , indicating that nsp4C may play a similar and conserved role in coronavirus replication. In summary, the crystal structure of MHV-A59 nsp4C reported here provides a preliminary structural description of coronavirus non-structural protein nsp4, further functional and structural studies of nsp4, together with its interaction with other virus and host cell proteins, will certainly boost our understanding the role of nsp4 in coronavirus replication.
Search related documents:
Co phrase search for related documents- coronavirus replication and host virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
- coronavirus replication and hydrophilic region: 1
- coronavirus replication and membrane topology: 1, 2
- crystal structure and host virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
- crystal structure and host virus cell protein: 1, 2
- crystal structure and non structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- crystal structure and sequence alignment: 1, 2, 3, 4, 5
- crystal structure and structural description: 1
- crystal structure and structural functional study: 1, 2, 3
- host virus and membrane topology: 1, 2
- host virus and non structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
- host virus and sequence alignment: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- host virus and structural description: 1
- host virus and structural functional study: 1
- host virus cell protein and non structural protein: 1, 2
- host virus cell protein interaction and non structural protein: 1
- membrane topology and non structural protein: 1
- non structural protein and sequence alignment: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- sequence alignment and understanding boost: 1
Co phrase search for related documents, hyperlinks ordered by date