Author: Shrestha, Ashish C.; Wijesundara, Danushka K.; Masavuli, Makutiro G.; Mekonnen, Zelalem A.; Gowans, Eric J.; Grubor-Bauk, Branka
Title: Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines Document date: 2019_4_30
ID: 141u6ax7_23
Snippet: Perforin (PRF) is a pore forming protein released by immune cells including NK cells and cytotoxic T lymphocytes (CTL) [91] . The 67-kilodalton PRF protein oligomerizes to form pores that serve as a channel to release granzyme into the cytosol of target cells [92] . Suicide genes inducing apoptosis of target cells have been used for cancer therapies, and the role of apoptotic cell death in vaccination, whether immune-stimulatory or immune-suppres.....
Document: Perforin (PRF) is a pore forming protein released by immune cells including NK cells and cytotoxic T lymphocytes (CTL) [91] . The 67-kilodalton PRF protein oligomerizes to form pores that serve as a channel to release granzyme into the cytosol of target cells [92] . Suicide genes inducing apoptosis of target cells have been used for cancer therapies, and the role of apoptotic cell death in vaccination, whether immune-stimulatory or immune-suppressive, is debated [93] . Recently, a novel DNA technology has been developed--termed cytolytic DNA technology-in which a truncated mouse PRF is incorporated in a bicistronic DNA vector to act as a vaccine adjuvant [55] [56] [57] 94] .
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