Selected article for: "antiviral activity and IFN Ï1"
Author: Wang, Xiaona; Li, Fengsai; Han, Meijing; Jia, Shuo; Wang, Li; Qiao, Xinyuan; Jiang, Yanping; Cui, Wen; Tang, Lijie; Li, Yijing; Xu, Yi-Gang
Title: Cloning, Prokaryotic Soluble Expression, and Analysis of Antiviral Activity of Two Novel Feline IFN-? Proteins
  • Document date: 2020_3_19
    • ID: 1me7ugkg_35
    Snippet: Next, we wanted to investigate whether the antiviral activities of the recombinant feIFN-ωa and feIFN-ωb proteins were also broad-spectrum. We performed MCIAs using a wide range of different viruses, including VSV, FCoV, CPV, BVDV, and PEDV. As shown in Figure 7 , rfeIFN-ωa and rfeIFN-ωb both displayed in vitro antiviral activity against VSV, FCoV, CPV, BVDV, and PEDV. Their antiviral activities were especially strong against FCoV and VSV. In.....
    Document: Next, we wanted to investigate whether the antiviral activities of the recombinant feIFN-ωa and feIFN-ωb proteins were also broad-spectrum. We performed MCIAs using a wide range of different viruses, including VSV, FCoV, CPV, BVDV, and PEDV. As shown in Figure 7 , rfeIFN-ωa and rfeIFN-ωb both displayed in vitro antiviral activity against VSV, FCoV, CPV, BVDV, and PEDV. Their antiviral activities were especially strong against FCoV and VSV. In contrast, the antiviral activity of rfeIFN-ωb against FCoV and VSV was significantly stronger than that of rfeIFN-ωa. No notable differences were observed between rfeIFN-ωa and rfeIFN-ωb with CPV, BVDV, or PEDV. In addition, the antiviral activity of rfeIFN-ωb against FCoV and VSV was significantly stronger than that of INTERCAT IFN, and the antiviral activities of both rfeIFN-ωa and rfeIFN-ωb against CPV, BVDV, and PEDV were significantly higher than that of INTERCAT IFN. In fact, we observed no antiviral activity against BVDV or PEDV by INTERCAT IFN. Unsurprisingly, there was no antiviral activity detected in cells' control groups (cells untreated with the IFNs). Figure 7 . The broad-spectrum antiviral activities of rfeIFN-ωa and rfeIFN-ωb using INTERCAT IFN for comparison. Bars represent the mean ± SEM for each group. Significant differences (* p < 0.05; ** p < 0.01; *** p < 0.001) were observed when comparing the rfeIFN-ωa/rfeIFN-ωb groups to the Figure 7 . The broad-spectrum antiviral activities of rfeIFN-ωa and rfeIFN-ωb using INTERCAT IFN for comparison. Bars represent the mean ± SEM for each group. Significant differences (* p < 0.05; ** p < 0.01; *** p < 0.001) were observed when comparing the rfeIFN-ωa/rfeIFN-ωb groups to the INTERCAT IFN group. A comparison of the rfeIFN-ωb group and rfeIFN-ωa group also indicated significant differences (# p < 0.05).

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