Author: Wang, Xiaona; Li, Fengsai; Han, Meijing; Jia, Shuo; Wang, Li; Qiao, Xinyuan; Jiang, Yanping; Cui, Wen; Tang, Lijie; Li, Yijing; Xu, Yi-Gang
Title: Cloning, Prokaryotic Soluble Expression, and Analysis of Antiviral Activity of Two Novel Feline IFN-? Proteins Document date: 2020_3_19
ID: 1me7ugkg_41
Snippet: Recently, combination antiviral therapy has become a common practice in treating feline viral infections due to pharmacokinetics and the short half-life of IFN alone [48, 49] . There are many published studies focused on the combination of IFN-ω with other therapeutic agents, such as chemotherapeutic agents [50] , IFN-α [51] , and ribavirin [6] , suggesting this is an attractive strategy to use against viral infections. We further evaluated the.....
Document: Recently, combination antiviral therapy has become a common practice in treating feline viral infections due to pharmacokinetics and the short half-life of IFN alone [48, 49] . There are many published studies focused on the combination of IFN-ω with other therapeutic agents, such as chemotherapeutic agents [50] , IFN-α [51] , and ribavirin [6] , suggesting this is an attractive strategy to use against viral infections. We further evaluated the antiviral effects of rfeIFN-ωa and rfeIFN-ωb combined with feline IL-18 against VSV and FCoV in F81 cells. Our results revealed that the in vitro antiviral activity of combination therapy was significantly increased compared to that of rfeIFN-ωa or rfeIFN-ωb alone, indicating that rfeIFN-ω combination therapy may represent a more potent option than monotherapy for treating viral infections in cats; however, this hypothesis requires further exploration in vivo. In summary, the rfeIFN-ωa and rfeIFN-ωb obtained in this study exhibit significant broad-spectrum antiviral activity in both homologous and heterologous cells in vitro, particularly rfeIFN-ωb, suggesting a promising candidate for the development of an effective therapeutic agent against viral infections in cats and other animals.
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