Selected article for: "high vaccine and immunity elicit"
Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox
  • Document date: 2012_3_1
    • ID: 0mmtcbof_4
    Snippet: There is more historical evidence correlating protection against smallpox with VACV neutralizing antibodies [37, 38] . Indeed, recent studies with orthopoxvirus challenge infections in animal models support the supposed protective role of antibody responses elicited by VACV immunization [39, 40] . Interestingly, very comparable levels of VACV neutralizing antibodies are found after MVA or conventional VACV (Dryvax) immunization [27] . In addition.....
    Document: There is more historical evidence correlating protection against smallpox with VACV neutralizing antibodies [37, 38] . Indeed, recent studies with orthopoxvirus challenge infections in animal models support the supposed protective role of antibody responses elicited by VACV immunization [39, 40] . Interestingly, very comparable levels of VACV neutralizing antibodies are found after MVA or conventional VACV (Dryvax) immunization [27] . In addition, MVA immunization can induce VACV specific antibody responses slightly earlier than conventional VACV (Elstree/Lister or Dryvax) in mice or non-human primates [39, 41] . Moreover, VACV vaccination of mice and macaques can result in full protection from lethal disease if administered shortly before or even after infection with virulent orthopoxviruses [39, [41] [42] [43] . In such cases rapid protection was associated with relatively high doses of vaccine, which may elicit earlier induction of antigen-specific immunity [39, 41, 43] .

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