Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_33
Snippet: Genes associated with MDR were also evaluated as target of RNAi, such as ribophorin II (RPN2) [106] , B-cell lymphoma 2 (BCL-2) [112] and multidrug resistance protein 1 (MRP1) [110] . RPN2 is known to be associated with the apoptosis in docetaxel-resistant human breast cancer cells [113] , and its involvement in NSCLC was investigated recently [114] . A novel RNAi molecule (PnkRNA) targeting RPN2 was developed and delivered to mice bearing lung c.....
Document: Genes associated with MDR were also evaluated as target of RNAi, such as ribophorin II (RPN2) [106] , B-cell lymphoma 2 (BCL-2) [112] and multidrug resistance protein 1 (MRP1) [110] . RPN2 is known to be associated with the apoptosis in docetaxel-resistant human breast cancer cells [113] , and its involvement in NSCLC was investigated recently [114] . A novel RNAi molecule (PnkRNA) targeting RPN2 was developed and delivered to mice bearing lung cancer by intrapulmonary delivery. This new class of RNAi agent has a unique helical structure containing a central stem and two loops, and is claimed to be stable against nuclease degradation. Inhibition of lung tumor growth was observed without any signs of toxicity after treatment. The antitumor effect was triggered by PnkRNA targeting RPN2 without the use of other anticancer drugs. It could be attributed to the multiple activities of RPN2, which is anti-apoptotic and involved in the regulation of tumor survival [106] . However, the mechanism of how the naked the PnkRNA molecules overcame the extracellular and intracellular barriers to initiate RNAi was not elucidated.
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