Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_69
Snippet: Most of the key signaling molecules involved in the pathogenesis of respiratory inflammatory disorders have multiple functions and participate in normal physiological activities to maintain homeostasis. Short-term regimen (up to four days) was employed in the majority of the animal studies. The duration of treatment may not be sufficient to observe any long-term effect. Since many inflammatory diseases are chronic disorders, long-term therapy is .....
Document: Most of the key signaling molecules involved in the pathogenesis of respiratory inflammatory disorders have multiple functions and participate in normal physiological activities to maintain homeostasis. Short-term regimen (up to four days) was employed in the majority of the animal studies. The duration of treatment may not be sufficient to observe any long-term effect. Since many inflammatory diseases are chronic disorders, long-term therapy is often required to control the disease. Therefore, it is crucial to evaluate the long-term effect of any RNAi therapeutics.
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