Author: Schmaljohn, Alan L.; Orlandi, Chiara; Lewis, George K.
Title: Deciphering Fc-mediated Antiviral Antibody Functions in Animal Models Document date: 2019_7_17
ID: 1755sywc_30
Snippet: Proceeding from the bottommost variable illustrated in Figure 4 , the importance of Ab affinity for its cognate viral epitope is well-known and foundational in immunology. As a general rule, higher affinity Abs are more active in most in vitro assays, and in protection. However, affinity is less an intrinsic property of Ab-epitope interaction than a measurement that can depend (over several orders of magnitude) upon epitope framework, conformatio.....
Document: Proceeding from the bottommost variable illustrated in Figure 4 , the importance of Ab affinity for its cognate viral epitope is well-known and foundational in immunology. As a general rule, higher affinity Abs are more active in most in vitro assays, and in protection. However, affinity is less an intrinsic property of Ab-epitope interaction than a measurement that can depend (over several orders of magnitude) upon epitope framework, conformation, epitope masking, and dynamic changes (rearrangements) that can occur for example when viral spikes encounter receptors, proteases, or pH changes (4, 5, 54) .
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