Author: Schmaljohn, Alan L.; Orlandi, Chiara; Lewis, George K.
Title: Deciphering Fc-mediated Antiviral Antibody Functions in Animal Models Document date: 2019_7_17
ID: 1755sywc_15
Snippet: "Fc-independent" Ab-binding is sufficient. Fe serves only half-life and valency "Fc-dependent" Ab-binding is necessary but insufficient. Fe is required for one or more functions • "Neutralization" i.e., Abs that act solely as antagonists of viral binding, entry, or launch as in many common assays • Aggregation of virions to functionally suppress numbers of infectious units......
Document: "Fc-independent" Ab-binding is sufficient. Fe serves only half-life and valency "Fc-dependent" Ab-binding is necessary but insufficient. Fe is required for one or more functions • "Neutralization" i.e., Abs that act solely as antagonists of viral binding, entry, or launch as in many common assays • Aggregation of virions to functionally suppress numbers of infectious units.
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