Selected article for: "acute form and lung disease"
Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside
  • Document date: 2016_9_20
    • ID: 04pp3lv0_64
    Snippet: ALI is a severe form of diffuse lung disease that is commonly caused by acute systemic inflammatory disorders, such as sepsis, pneumonia, trauma and pancreatitis [11, 212] . It is a progressive disease, which can lead to acute respiratory distress syndrome (ARDS) or more critically, multiple organ failure and even death [175] . Its pathological changes include the release of pro-inflammatory cytokines and chemokines, and the destruction of the ep.....
    Document: ALI is a severe form of diffuse lung disease that is commonly caused by acute systemic inflammatory disorders, such as sepsis, pneumonia, trauma and pancreatitis [11, 212] . It is a progressive disease, which can lead to acute respiratory distress syndrome (ARDS) or more critically, multiple organ failure and even death [175] . Its pathological changes include the release of pro-inflammatory cytokines and chemokines, and the destruction of the epithelium-capillary interface; the latter can facilitate the extravasation of protein-rich fluid and the infiltration of neutrophils, thereby exacerbating the condition [213, 214] . Since the molecular mechanism underlying the pathology of ALI is not well understood, there is no pathophysiologic-driven therapeutic approach available [162] .

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