Author: Zheng, Jie; Tan, Boon Huan; Sugrue, Richard; Tang, Kai
Title: Current Approaches on Viral Infection: Proteomics and Functional Validations Document date: 2012_11_16
ID: 1grbdlib_42
Snippet: What is more, these emerging large-scale screening technologies have tremendous impact on deciphering pathogen-host interplays. For instance, antiviral immune responses by production of type-I IFNs upon virus infection are regulated by TANK-binding kinase 1 (TBK1) and I-kB kinase ε (IKKi). TBK1 was observed to play a more profound role than IKKi (Hemmi et al., 2004) . To understand the molecular interacting network of TBK1/IKKi involved in regul.....
Document: What is more, these emerging large-scale screening technologies have tremendous impact on deciphering pathogen-host interplays. For instance, antiviral immune responses by production of type-I IFNs upon virus infection are regulated by TANK-binding kinase 1 (TBK1) and I-kB kinase ε (IKKi). TBK1 was observed to play a more profound role than IKKi (Hemmi et al., 2004) . To understand the molecular interacting network of TBK1/IKKi involved in regulating IFNs upon virus infections, Goncalves et al. employed TAP based MS to study interacting partners of TBK1, IKKi, and their corresponding adaptor proteins, TANK, Sintbad, and NAP1. Consequently, MS identified 30 binding partners of these five proteins, representing a small interaction network of TBK1 and IKKi. Using RNA based microarray assay, overall changes at the transcription level were illustrated by intensity in response to virus infection or poly (I:C) simulation, and it was found that TBK1-TANK binding contributed greatly to the TBK1 activation (Goncalves et al., 2011) . Clinically, high throughput proteome microarray bearing antigens of HPVs was able to examine immune responses and antigenicity of HPV proteins in a vast number of patients' serum samples (Luevano et al., 2010) .
Search related documents:
Co phrase search for related documents- adaptor protein and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- adaptor protein and interaction network: 1, 2
- adaptor protein and pathogen host: 1, 2, 3, 4
- adaptor protein and TBK1 activation: 1, 2, 3, 4, 5
- adaptor protein and TBK1 IKKi: 1, 2
- adaptor protein and type production: 1, 2, 3, 4, 5, 6, 7, 8, 9
- adaptor protein and type production immune response: 1
- adaptor protein and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- adaptor protein and virus infection ifn: 1, 2
- antiviral type production immune response and immune response: 1, 2
- antiviral type production immune response and type production: 1, 2
- antiviral type production immune response and type production immune response: 1, 2
- antiviral type production immune response and virus infection: 1
Co phrase search for related documents, hyperlinks ordered by date