Selected article for: "allergic sensitization and atopic asthma"
Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside
  • Document date: 2016_9_20
    • ID: 04pp3lv0_54
    Snippet: In allergic asthma, there is predominant activation of CD4 + T helper 2 (T h 2) cell-driven inflammatory response [183] . T cell activation and T h 2 cytokine expression are increased in the airways of atopic asthma patients after exposure to allergen [184] . T h 2-type cytokines, interleukin-4 (IL-4), IL-5 and IL-13, are the main players in the pathology of allergic airway inflammation, contributing to allergic sensitization, IgE production, eos.....
    Document: In allergic asthma, there is predominant activation of CD4 + T helper 2 (T h 2) cell-driven inflammatory response [183] . T cell activation and T h 2 cytokine expression are increased in the airways of atopic asthma patients after exposure to allergen [184] . T h 2-type cytokines, interleukin-4 (IL-4), IL-5 and IL-13, are the main players in the pathology of allergic airway inflammation, contributing to allergic sensitization, IgE production, eosinophil infiltration and AHR respectively [183, 184] . Clinical studies that examine the therapeutic potential of using monoclonal antibodies (mAbs) to neutralize the bioactivity of IL-4 [185] , IL-13 [186, 187] and IL-5 [188] or target their receptors are in progress. Similarly, RNAi technology can be employed to target these cytokines [169, 181] .

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